Not only a substantial iron reservoir was observed in the inflammatory stromal cells from the primary tumors and axillary lymph nodes of breast cancer, but the malignant cells also exhibited an iron acquisition characteristic by overexpressing hepcidin and transferrin receptor 1 (TFR1) and concomitantly downregulating ferritin, whereas the TAMs within the TME manifested an iron delivery feature by expressing ferroportin and ferritin [106]. The gene discussed is TFRC; the disease is breast carcinoma.