There were 3.75% of the interactors which were common to both pathways of cancer and CRC, namely, PIK3CD, AKT1, AKT3, BAX, BIRC5, GSK3B, MAPK1, MYC, PIK3CG, PIK3R2, RAC1, RAF1, RHOA, SMAD2, SMAD4, TGFB1, and TGFBR1. This evidence concerns the gene MAPK1 and cancer.