SMAD4 and colorectal carcinoma: The known mRNA interactors of miR-122 include PKM2, AKT1, MYC, TGFBR1, and SMAD4 in hepatocellular carcinoma (Figure 4b) [25], JNK, AP1, and caspases 3/8 in irritable bowel disease [26], and AKT, PI3K, PCNA, MTDH [15], PI3K, TRIM29, Bcl-W, CCNG1 [11], and ALDO2 [14] in CRC.