There were 3.75% of the interactors which were common to both pathways of cancer and CRC, namely, PIK3CD, AKT1, AKT3, BAX, BIRC5, GSK3B, MAPK1, MYC, PIK3CG, PIK3R2, RAC1, RAF1, RHOA, SMAD2, SMAD4, TGFB1, and TGFBR1. Here, SMAD2 is linked to colorectal carcinoma.