SMAD4 and cancer: A comparative analysis of miR-122 interactors in different pathways describes the presence of several genes associated with CRC including SMAD4, TGFBR1, AKT, MYC, Rho, Ras, Raf, Bax, and CDK 4/6 to actively engage in hepatocellular carcinoma and other pathways of cancer (Figure 4a–c).