In a mouse model, overexpression of SETBP1 in hematopoietic progenitors resulted in the development of myeloid leukemia characterized by reduced expression of RUNX1 due to deacetylation of histones in the gene promoter mediated by Histone deacetylase 1 (HDAC1) [50]. The gene discussed is HDAC1; the disease is myeloid leukemia.