The histopathological hallmarks of AD are the accumulation of extracellular senile plaques consisting of amyloid-β (Aβ) peptides [1] and of intracellular neurofibrillary tangles (NFTs), composed of aggregated abnormally hyperphosphorylated microtubule-associated protein tau [2], as well as neuroinflammation and neuronal and synaptic loss. This evidence concerns the gene MAPT and Alzheimer disease.