In BC, CAFs-derived small nucleolar RNA host gene 3 (SNHG3), a long non-coding RNA (lncRNA) that functions as a molecular sponge of miR-330-5p to upregulate pyruvate kinase M1/M2 (PKM) expression in sEVs, has a potential role in the inhibition of mitochondrial oxidative phosphorylation and the promotion of breast tumor cell proliferation [139]. The gene discussed is SNHG3; the disease is breast cancer.