Another clinical study of sEVs microRNA signatured in 20 healthy women and 435 BC patients demonstrated that 10 miRNAs in the entire BC patient cohort, 13 miRNAs in the HER2+ subgroup, and 17 miRNAs in the triple-negative subgroup were significantly deregulated, compared to those in healthy women, indicating different aspects of cancer biology in different BC types [62]. This evidence concerns the gene ERBB2 and cancer.