TNF and neoplasm: Tumor-derived sEVs contain a variety of angiogenic factors, including VEGF, fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α), and IL-8 [82,83].