In the present study, we aimed (a) to determine the temporal profile of circulating NF-L, (b) to assess associations between plasma NF-L levels and the evolution of cortical damage, and (c) to determine whether NF-L could be used as a sensitive and specific prognostic biomarker to predict the functional outcome after TBI, focusing on somatomotor recovery, cognitive decline, and epileptogenesis. Here, NEFL is linked to Mental deterioration.