PTEN and neoplasm: In the ovarian pathology area, circRNAs show tumor-promoting properties by either increase OC cell proliferation, invasion and migration through PTEN/PI3k/AKT, JAK/STAT, and MAPK signalings or indirectly exert the suppression mechanisms, such as apoptosis, ferroptosis and autophagy pathways through PPARγ, Hippo or Rho GTPase signalings.