PTEN and colorectal cancer: miR-186-5p is also a well-studied miRNA that exhibits complex effects in tumors, such as playing a positive role in lung adenocarcinoma by targeting PTEN [43] and inhibiting tumor growth in osteosarcoma [44], non-small-cell lung cancer cells (NSCLCs) [45], colorectal cancer cell [46], and neuroblastoma [47].