Accordingly, the striatal and hippocampal gene expression signatures of pre-symptomatic HD mice showed overlap with the transcriptional profiles of mice lacking specific histone-modifying enzymes, including the histone methyltransferases G9a (euchromatic histone-lysine N-methyltransferase 2, EHMT2), GLP (G9a-like protein, EMHT1) and EZH1/EZH2 (enhancer of zeste 1 and 2), and the histone acetyltransferase (HAT) CBP (CREB-binding protein) [12]. Here, CREBBP is linked to Huntington disease.