HTT and Huntington disease: To this end, we generated PTM mimetic His3.3A constructs with point mutations mimicking unmodified, acetylated, or methylated lysines at positions 9, 14, or 27 and tested them in a Drosophila HD model, which was based on elav-GAL4-driven neuron-specific expression of the first exon of human HTT with an elongated CAG repeat encoding for 120 glutamines (HTTex1.Q120) [21].