In symptomatic HD mice, the acetylation of histone H3 was found to be decreased at specific gene promoters in the absence of bulk changes in H3 acetylation [15], and the genome-wide analysis of striatal samples showed that the level of H3K9/K14 acetylation on gene sequences and the number of genes with H3 acetylation were both decreased [16]. Here, KRT14 is linked to Huntington disease.