TNF and neoplasm: Dysplastic aberrant crypt foci (ACFs) were also detected along the colon length of 5-wk-old Winnie-ApcMin/+-TNF-KO mice, with an increased frequency moving distally towards the rectum (Table 1 and Supplementary Figure S1), even if their incidence, multiplicity, and tumor grading were substantially reduced compared with age-matched Winnie-ApcMin/+ mice [28] (Table 1).