TNF and inflammatory bowel disease: Based on the importance of TNF in IBD pathogenesis and on the established efficacy of anti-TNF biologics in clinical practice, and taking advantage of our previous established model of CAC (the Winnie-ApcMin/+ model [28]), we developed Winnie-ApcMin/+ mice lacking TNF by crossing commercially-available Tnf null mice (line TNF-KO) [30] with Winnie-ApcMin/+ mice.