Surprisingly, the absence of TNF induced a more aggressive phenotype for the tumoral lesions in Winnie-ApcMin/+-TNF-KO mice because of the altered mechanisms involved in carcinogenesis, tumor microenvironment, and cellular remodeling; thus, this observation supports the presence of the “advanced malignant tumor” disease and functions among the top regulator effect networks in the context of gastrointestinal disease, which was identified by the IPA. This evidence concerns the gene TNF and gastrointestinal disease.