To further assess the impact of HIV infection and associated excessive BAFF condition on the dysregulation of MZp, we FACS-sorted MZ and MZp B-cell populations from the blood of three PHI progressors (5–8 months), three ECs and three controls selected from the above-mentioned study [3], and proceeded to transcriptomic analyses by RNA-seq. The gene discussed is TNFSF13B; the disease is HIV infectious disease.