Similar to that observed for SLE and other rheumatic disorders, there is growing evidence that BAFF is in excess in contexts of cancer, and could also play a role in the pathogenesis of several inflammatory chronicity, such as multiple sclerosis and HBV infection [32], suggesting that excess BAFF and dysregulated MZp may be important indicators of deterioration of immunocompetence. The gene discussed is TNFSF13B; the disease is systemic lupus erythematosus.