KCNQ2 and Epileptic encephalopathy: Similarly, the pathogenicity of the gain-of-function mutations in Kv7.2 and Kv7.3 K+ channels found in patients with epileptic encephalopathies, which increase the open probability of the channels at the resting membrane potential, was also suggested to be due to a decreased excitability of the inhibitory neurons and disinhibition of the neuronal circuits [24].