Cerquieira et al. identified the TLR7/TLR8 locus associated with CD onset before seven years of age, whereas the SH2B3/ATXN2, ITGA4/UBE2E3, and IL2/IL21 loci were associated with later development of CD and a more severe mucosal injury [19]. This evidence concerns the gene TLR8 and Cowden disease.