A panel of small-molecule inhibitors of MDM2, including RG7112, RG7388, AMG-232, APG-115, BI-907828, CGM097, sirmadlin, milademetan, SAR405838, MK-8242, PRIMA1, and APR-246, is undergoing clinical trials investigating their therapeutic effects on cancers (Table 2) [145,146,147]. Here, MDM2 is linked to cancer.