TGFB1 and Hepatic fibrosis: The propagation of liver fibrosis is depicted in a so-called adverse outcome pathway (AOP) featuring a series of key events: hepatocyte death/injury leads to Kupffer cell activation, which subsequently releases the pro-fibrogenic cytokine transforming growth factor beta 1 (TGF-β1) to activate hepatic stellate cells (HSCs) [11].