ITM2B and Alzheimer disease: These five up-regulated proteins also include an integral membrane protein (ITM2B) involved in the inhibition of synthesis of the precursor of β-amyloid (Aβ) peptide, predisposing the fibrillar deposition of Aβ peptide in neurodegenerative syndromes, such as AD, and finally a ribosomal protein, ubiquitin-60S L40 (RL40).