When comparing phlegmonous appendicitis values with those of NPA, the difference was significant (p = 0.01): IL-4 (48.3 vs. 21.3 pg/mL), IL-5 (29.2 vs. 8.0 pg/mL), and IL-9 (34.1 vs. 16.6 pg/mL). Here, IL5 is linked to appendicitis.