Allergy, expressed as an immune response to environmental antigens (allergens) that involve Th2 cells, mast cells, eosinophils, and immunoglobulin E (IgE) [13], is a suitable trigger for AA, as the digestive tract is challenged by thousands of antigens daily and the immune system can react against otherwise harmless environmental agents [8,14]. This evidence concerns the gene IGHE and allergic disease.