Finally, experiments performed in an orthotopic and heterotopic pancreatic ductal adenocarcinoma (PDAC) model, demonstrated that B4GALT1 belongs to a new signaling pathway, including p65 upstream and CDK11p110 downstream, respectively, involved in chemoresistance of pancreatic cancer [14]. Here, B4GALT1 is linked to pancreatic ductal adenocarcinoma.