Considering the higher production of IFN-γ by tumour-bearing mice treated with the parasite lysate, the functional role of M1-like tumour-associated macrophages in the elicited immune response, such as tumour cell killing by reactive oxygen and nitrogen species, activating NK cells and promoting Th1 and cytotoxic immune responses [31], should be investigated. This evidence concerns the gene IFNG and neoplasm.