Recent studies suggest that ROS, Polypeptide growth factor, NF-κB, PI3K/AKT, epigenetic factors (MicroRNAs), Wnt/β-catenin, and Notch are all triggers involved in EMT in radiation-induced pulmonary fibrosis [1,2,3,4,5,6,7,8,9,24]. This evidence concerns the gene AKT1 and pulmonary fibrosis.