A study by Tian et al. evidenced that Kruppel-like factor 5 (KLF5), a pro-apoptotic member of the Kruppel-like transcription factor family, induces cell and tissue damage in myocardial infarction (MI) through downregulation of miR-27a and the subsequent activation of GFPT2/TGF-β/Smad2/3 axis (Figure 2) [31]. The gene discussed is SMAD2; the disease is myocardial infarction.