According to the big data analysis performed on the database, the direct links with high-risk genes/alleles in the production of a myocardial infarction are represented by: PAI-1, PIA2, R353Q, H7H5, H7H6, C242T, Stromelysin-1, IL genes 5A-1171/6A, LTA, LGALS2, AT2 (−1332 G/A), RS671, LDLR, AKAP12, OR8D2, GLRA2, G894T, pro12ala, factor V genes, 4G/5G, 5’-franklin region from nitric-oxide synthase gene, ppar-gamma, glu298asp variant, and PCSK9. The gene discussed is SERPINE1; the disease is myocardial infarction.