The big data analysis revealed the most relevant genes/alleles that present an increased risk of myocardial infarction, represented by: PAI-1, Stromelysin-1, 5A-1171/6A, LTA, LGALS2, AT2 (−1332 G/A), RS671, LDLR, AKAP12, OR8D2, GLRA2, the 5’-franklin region of the nitric-oxide synthase gene. The gene discussed is LDLR; the disease is myocardial infarction.