In CML cells, CA directs CML cells towards apoptosis through the caspase cascade with a mechanism that required the presence of TG2 in an active form since both caspases activation and extroversion of the phosphatidylserine were strongly reduced in the presence of the TG2 inhibitor (Figure 5). This evidence concerns the gene TGM2 and chronic myelogenous leukemia, BCR-ABL1 positive.