STAT1 and melanoma: Evaluation of the innate immune signaling activation confirmed the reported effects on targeted pathways, characterized by decreased phosphorylation of STAT1 together with decreased expression of melanoma differentiation-associated gene 5 (MDA5), although results for this intracellular RNA sensor belonging to the Retinoic acid-inducible gene I-like receptors (RLRs) family were statistically non-significant (Figure 2C).