Thus, because RLA rats, but not their RHA counterparts, are predisposed to displaying depression-like behaviors when exposed to FS [19,20], we predicted that acute stress would elicit more pronounced changes in BDNF and trkB protein levels (either an increase or a decrease) in the mesolimbic DA system of RLA vs. RHA rats. The gene discussed is NTRK2; the disease is depressive disorder.