Indeed, when comparing T-cell CD4 subset distribution at both T0 and T1 in PLWH and HD, a statistically significant difference was observed (p = 0.0562 and p = 0.0018, respectively) as well as in T-cell CD8 subset distribution at T1 (p = 0.0001) (Figure 1B). Here, CD8A is linked to Huntington disease.