TIMP3 and skin cancer: Table 3 shows the relationship between the TIMP3 promoter genotype and the risk of skin cancer. Although not statistically significant, there was a trend toward a positive association between the skin cancer risk with carriers of the SNPs of the rs9619311 C allele and rs2234921 G allele. In the haplotype analysis, no single diplotype was significantly associated with the risk of skin cancer (Table S2).