INS and obesity due to melanocortin 4 receptor deficiency: An increase in white adipose tissue (WAT) in obesity, namely its visceral depot (vWAT), affects the secretion of adipokines and is associated with metabolic (obesity, insulin resistance, type 2 diabetes) and cardiovascular diseases due to the properties of vWAT adipocytes, which include reduced sensitivity to insulin, low angiogenic potential, and increased lipolytic activity [8,9,10].