Several FH genes related to LDL-C metabolism have been identified to cause FH, namely, low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), proprotein convertase subtilisin/kexin-type 9 (PCSK9) and LDL receptor adaptor protein 1 (LDLRAP1) genes. This evidence concerns the gene PCSK9 and familial hyperaldosteronism.