We found that overexpression of ZNF71 in A549 lung adenocarcinoma cells resulted in the downregulation of multiple components of the intracellular intrinsic and innate immune systems, including dsRNA (OAS1) and dsDNA (STING, pTBK1) sensors and viral restriction factors (TRIM5, SAMDH1) (Figure 4). Here, TRIM5 is linked to lung adenocarcinoma.