The activated kinases initiate a cascade of protein phosphorylation involving multiple kinases and activate nuclear transcription factors, such as NF-KB, e.g., that the expression levels of TNF-α, IL-1β, and IL-6 were downregulated in BAC-induced dry eye after treatment with KIOM-2015E. The gene discussed is TNF; the disease is Keratoconjunctivitis sicca.