DNAJB6 and neoplasm: It has been further revealed that the DNAJB6-HSPA8 (HSP70) complex in PP2A-dependent dephosphorylation of GSK3β as a client protein can reduce the abundance of β-catenin and subsequent loss of TCF/LEF (T cell factor 1/lymphoid enhancer factor1) activity, leading to suppression of EMT, tumor growth, and metastasis potential in breast and melanoma cancers [87].