Mechanistically, DNAJB9 can interact with FBXO45 (F-box/SPRY domain-containing protein 1) ubiquitin ligase to promote FBXO45 protein stability, which reduces the abundance of ZEB1 by proteasomal degradation, leading to repressed EMT, invasion, and metastasis of breast cancer cells [100]. This evidence concerns the gene DNAJB9 and breast cancer.