Accumulating studies have reported that DNAJB6 could regulate not only various cellular physiological events such as cell polarity, cell morphology, stabilization, and mediation of protein–protein interaction but also plays diverse roles in multiple pathologies such as degenerative nervous system disorders, dementia, inherited myopathy, infectious viral diseases, and cancer [81,82,83,84]. The gene discussed is DNAJB6; the disease is cancer.