APOB and familial hypercholesterolemia: APOB variants have been extensively studied over the past three decades and more than 5000 polymorphic sites have been reported at the highly polymorphic APOB locus (https://www.ncbi.nlm.nih.gov/snp/?term=APOB, accessed on 25 June 2022), which may be associated with familial hypercholesterolemia or hypobetalipoproteinemia (HBLP) [10,11,12,13].