Previous GWAS and genetic association studies have shown significant association between rs676210 genotypes and apolipoprotein A1, HDL cholesterol and triglyceride and oxidized LDL levels as well as serum metabolite measurement and the response to fenofibrate therapy [32,33,34,35,36,37,38], and between rs679899 genotypes and HDL and LDL cholesterol and triglyceride levels and chronic kidney disease in hypertension [39,40,41]. The gene discussed is APOA1; the disease is hypertensive disorder.