There are reports that ADAM17 may be used as a diagnostic and prognostic marker of pulmonary fibrosis [375], while the ADAM33 concentration was increased in the BAL fluid of patients with sarcoidosis and inversely correlated with lung function and CO2 diffusion capacity, although no difference was discovered in the enzymatic activity of ADAM33 between healthy patients and patients with sarcoidosis [401] (Table 3). The gene discussed is ADAM17; the disease is sarcoidosis.