PLAT and pulmonary fibrosis: However, relatively new data point out that EMT may indirectly participate in pulmonary fibrosis development through the paracrine activation of fibroblasts by the transcriptional factor ZEB1, controlling the expression of tissue plasminogen activator (tPA)—one of the main stimulators of TGF-β-induced pro-fibrotic response in fibroblasts [147].