Moreover, in colon cancer cells where curcumin induces reactive oxygen species (ROS), curcumin was found to down-regulate microRNAs miR-27a, miR-20a, and miR-17-5p and regulate transcriptional repressors ZBTB10 and ZBTB4 [67]. Here, ZBTB10 is linked to malignant colon neoplasm.