Moreover, in colon cancer cells where curcumin induces reactive oxygen species (ROS), curcumin was found to down-regulate microRNAs miR-27a, miR-20a, and miR-17-5p and regulate transcriptional repressors ZBTB10 and ZBTB4 [67]. The gene discussed is ZBTB4; the disease is malignant colon neoplasm.