In a study by Girnita et al., the inhibition of N-glycosylation using inhibitors of N-glycan biosynthesis resulted in a remarkable decrease of IGF-1R autophosphorylation together with its reduced expression at the cell surface, which was accompanied by a substantial decrease in the survival of Ewing’s sarcoma cell lines [41]. This evidence concerns the gene IGF1R and Ewing sarcoma.