AR and posterior cortical atrophy: Therefore, cytotoxicity of each individual compound was determined in PCa cell lines harboring different levels of drug resistance, namely NHA-sensitive LNCaP cells (AR+), NHA-resistant 22Rv1 cells (AR+, AR-V7+), LASCPC-01 cells (NEPC), NHA-resistant and Doce-sensitive PC3 and DU145 cells (both are AR-) and their correspondent Doce-resistant counterparts PC3-DR and DU145-DR cells (Table 3).