INS and anemia (phenotype): Indeed, depletion of vitamins has been associated to a variety of human diseases, including neurologic and cardiovascular disorders (vitamin B1), weakness (vitamin B2), sensitivity to insulin (vitamin B5), immunodepression (vitamin B6), skin problems (vitamin B8) [47], anemia (vitamin B9) [48], blood coagulation (vitamin K2) [49] and epilepsy (lipoic acid) [50].