PRAME and neoplasm: Some of them are involved in meiosis and germ cell development, and some, particularly members of the Melanoma Antigen Gene (MAGE) family and PRAME, are implicated in the downregulation of the p53 tumour suppressor [52,53,54], epigenetic reprogramming to stemness, and germline initiation [55,56], along with suppression of differentiation [57] and poor clinical prognosis [56,58].