Additionally, we observed that miR-122 inhibition had a stronger effect in the sWAT, resulting in upregulation of direct target genes with beneficial effects on obesity—including Vav1, whose knockout displayed increased fat content by decreasing Sirt1 activity [60]; or Ntrk3, which promotes browning [61]. The gene discussed is NTRK3; the disease is obesity due to melanocortin 4 receptor deficiency.