TF and peripheral arterial disease: Several years ago, Blann et al., evaluated the concentration of tissue factor in the plasma of patients with PAD and healthy people, finding that TF levels were higher in the first group compared to the latter; in particular, this difference was statistically significant considering young people among the PAD group, pointing out a likely independent role of this coagulation factor in the development of peripheral artery disease, regardless of other possible confounders in the elderly patients [118].