VWF and peripheral arterial disease: Given the interconnection between the pathogenesis of PAD and coagulation, several studies have been conducted in order to evaluate abnormal values of clotting factors in patients affected with peripheral artery disease compared to the general population: in particular, some studies found a correlation between PAD and fibrinogen, D-dimer antigens, von Willebrand factor, and tissue plasminogen activator (tPA), whose levels appear to be higher in patients with PAD than in healthy subjects [115,116,117].