While recessive mutations of the TNSALP gene give rise to a more severe diseases manifesting early in childhood, adult hypophosphatasia is a genetically determined disorder of mineralization, usually determined by haploinsufficiency of TNSALP, in which osteomalacia in a part of a more complex clinical picture, characterized by multiple insufficiency fractures, chondrocalcinosis, osteoarthropathy, and dental abnormalities (early loss of primary and secondary teeth). This evidence concerns the gene ALPL and skeletal system disorder.