CYP2R1 and vitamin D-dependent rickets: The rare genetically determined disorders vitamin D-dependent rickets (VDDR) types 1A and 1B, caused by mutation in genes encoding cytochrome P450 family 27 subfamily B member 1, i.e., 1alpha-hydroxylase (CYP27B1) or cytochrome P450 Family 2 Subfamily R Member 1, i.e., 25-hydroxylase (CYP2R1), are included in the vitamin D-dependent forms of altered mineralization since they are cured with specific analogs of vitamin D, such as 1alpha-hydroxylated forms of vitamin D or 25-hydroxylated vitamin D, respectively [1,12].