Fibroblast growth factor (FGF) 1, FGF2, and FGF receptor 1 (FGFR1) have been shown to be overexpressed in AdCC and implicated in the carcinogenesis of AdCC upregulation of extracellular signal-regulated kinase and cyclin D1 and P21 signaling pathway [61,62]. This evidence concerns the gene CCND1 and adrenocortical carcinoma, hereditary.