Furthermore, in IHD hearts, the fluorescence intensity levels of both TRPM6 and TRPM7 were also enhanced in immunohistochemical analysis as follows: 1.40 ± 0.034 a.u. for TRPM6 and 2.14 ± 0.088 a.u. for TRPM7 in non-IHD vs. 1.91 ± 0.042 a.u. for TRPM6 and 3.01 ± 0.091 a.u. for TRPM6 in IHD (n = 15 each, p < 0.01, Figure 8B). Here, TRPM6 is linked to myocardial ischemia.