TP53 and cancer: Furthermore, overexpression of miR-18a-5p in ovarian epithelial cells induces apoptosis, cell cycle arrest, and decrease cancer growth in vivo through directly targeting cancer signaling pathways, such as tumor protein 53 (TP53), TP53 regulated inhibitor of apoptosis 1 (TRIAP1), and inositol phosphate multikinase (IPMK) [56].