Of the various combinations of interventions used in the 15 RCTs, we find that the single-species probiotic soy milk formulation consisting of 4 × 109 CFU/d Lactobacillus plantarum A7 [38,39,46] produced significant effects on T2D-DN patients without adverse events, modifying the most renal biomarkers, including serum Cr, eGFR, urine Alb/Cr, serum IL-18, sTNR1, Cys-C, and PGRN. This evidence concerns the gene IL18 and type 2 diabetes mellitus.