In the earlier discussed RCT by Abbasi et al. [38,39,46], probiotic soy milk containing Lactobacillus plantarum A7 could reduce IL-18 levels, whose serum concentration has been independently shown to correlate with DKD development and is utilized as a clinical marker for vulnerability and progression to advanced renal disease [108,109,110,111,112]. This evidence concerns the gene IL18 and diabetic kidney disease.