AKT1 and neoplasm: Regarding the molecular mechanism, for instance, activation of the AKT signaling pathway induces cell proliferation, lipogenesis, and tumor development in HCC [35]; hepatic expression of Nras(G12V) triggers oncogene-induced senescence [36]; coexpression of hMet and mutant-β-catenin activates hMet and Wnt pathways [37], thus leading to notable HCC in mice.