On the other hand, assessment of different single-targeting AChE inhibitors did not result in a homogenous comparable outcome, despite significant inhibition of the enzyme recorded in vitro [43], suggesting that inhibition of the AChE enzyme may modulate different AD pathways involved in the Tau hyperphosphorylation triggered by GA, but in a non-specific manner derived by the distribution and concentration of different acetylcholine receptors. Here, ACHE is linked to Alzheimer disease.