NR1I2 and irritable bowel syndrome: IBD draws on many of the features triggered by pathogen infection seen in COVID-19, with similarities in host pattern recognition receptor (PRR) identification of pathogens or damage associated molecular patterns (DAMPs) and release of TNF-α, IFN-γ, IL-6, IL-17 and NfκB by macrophage TLR4 receptor pathways, and a concomitant reduction of T-regulatory cells (Treg).