Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) that are genetic drivers for NAFLD, namely, patatin-like phospholipase domain containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2) and membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7) [23]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.