The PNPLA-3 variant rs738409 (C > G), which encodes PNPLA3 I148M (substitution of isoleucine to methionine at position 148), resists degradation and is associated with increased hepatic fat content, with a high frequency of this risk allele in concordance with the high prevalence of NAFLD among Hispanics [98]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.